Animal Disease Vaccines

  • 1 What is Foot-and-Mouth Disease (FMD)?

    Foot-and-Mouth Disease (FMD) is a highly contagious viral disease that affects cloven-hoofed livestock such as cattle, pigs, and sheep.

    Animals infected with the Foot-and-Mouth Disease Virus (FMDV) exhibit symptoms such as high fever, blisters, and ulcers. Due to its rapid transmission, FMD can cause significant economic damage to the livestock industry, making vaccination an essential preventive measure.

  • 2 Global Status of FMD Outbreaks

  • 3 Conventional FMDV Vaccines

    FMDV is classified as a Bio-Safety Level 3 (BSL-3) high-risk virus.

    Traditional inactivated vaccines require the cultivation of live virus during production, which introduces several biosafety risks throughout the manufacturing process.

    Moreover, these vaccines often exhibit limited duration of immunity, necessitating regular booster vaccinations to maintain protection.

  • 4 Nanovax’s FMDV Vaccine

    VLP-based vaccine development and manufacturing does not require the use of live virus, making the production process significantly safer.

    It elicits an immune response similar to natural infection, resulting in strong and long-lasting immunity.

    Furthermore, VLP vaccines can be rapidly adapted to respond to various viral mutations through simple genetic recombination.

    Nanovax Co., Ltd. is developing an effective and cost-efficient Foot-and-Mouth Disease (FMD) vaccine using an E. coli-based VLP expression system.

    A-type FMD VLPs

    O-type FMD VLPs

    Asia1-type FMD VLPs

  • 1 What is Porcine Circovirus Type 2 (PCV2)?

    Porcine Circovirus Type 2 (PCV2) is a highly prevalent virus in pig farms, with a reported positivity rate of 78.2%. It is associated with a range of diseases, including Porcine Dermatitis and Nephropathy Syndrome (PDNS), Postweaning Multisystemic Wasting Syndrome (PMWS), and Porcine Respiratory Disease Complex (PRDC), all of which can significantly impact swine health and farm productivity.

  • 2 The Importance of PCV2 Vaccination

    PCV2 is a virus with multiple genotypes, among which PCV2b and PCV2d are known to be highly pathogenic. In particular, PCV2d is the most prevalent genotype in Korea, with a 76% positivity rate (including co-infections).

    The current PCV2 vaccine market in Korea is estimated to exceed KRW 40 billion, and the majority of vaccines are imported. This highlights an urgent need for local vaccine development and production to ensure supply stability and national biosecurity.

    Distribution of PCV2 Genotypes in Korea

  • 3 Nanovax’s PCV2 Vaccine

    Nanovax Co., Ltd. is developing an effective and cost-efficient PCV2d vaccine using an E. coli-based VLP expression platform.

    WB analysis

    TEM analysis

    DLS analysis